|Year : 2015 | Volume
| Issue : 5 | Page : 335-340
|Essential oils, their therapeutic properties, and implication in dentistry: A review
Namrata Dagli1, Rushabh Dagli2, Rasha Said Mahmoud3, Kusai Baroudi3
1 Ethics Committee, Care Institute of Medical Sciences, Ahmedabad, Gujarat, India
2 Department of Public Health Dentistry, Vyas Dental College and Hospital, Jodhpur, Rajasthan, India
3 Department of Preventive Dental Science, Alfarabi Colleges, Riyadh, Saudi Arabia
|Date of Web Publication||22-Sep-2015|
Care Institute of Medical Sciences, Ahmedabad, Gujarat
Source of Support: Nil., Conflict of Interest: None declared.
| Abstract|| |
Background Antibacterial treatments currently used for treatment cause several side effects, and bacterial resistance to the antibiotics is also increasing. Therefore, there is need to find better alternatives. Essential oils (EOs) have been used for treatment of various ailments since ancient times and have gained popularity over the years. Safety and efficacy of EOs have been proved by several clinical trials. This review gives an overview on the EOs, their uses, and adverse effects. Materials and Methods: A literature search was performed in the PubMed for clinical trial studies and review articles on EOs published up to February 2015. The search was performed during March 2015. The following keywords were used: “Lavender essential oil,” “cinnamon oil,” “clove oil,” “eucalyptus oil,” “peppermint oil,” “lemon EOs,” and “tea tree oil.” Results: Total 70 relevant articles were found in PubMed database. After screening of abstracts, 52 articles were selected to be included in the present review. Conclusion: On the basis of the available information, it can be concluded that EOs have the potential to be developed as preventive or therapeutic agents for various oral diseases, but further clinical trials are required to establish their safety and efficacy.
Keywords: Alternative medicine, essential oils, oral pathogens
|How to cite this article:|
Dagli N, Dagli R, Mahmoud RS, Baroudi K. Essential oils, their therapeutic properties, and implication in dentistry: A review. J Int Soc Prevent Communit Dent 2015;5:335-40
|How to cite this URL:|
Dagli N, Dagli R, Mahmoud RS, Baroudi K. Essential oils, their therapeutic properties, and implication in dentistry: A review. J Int Soc Prevent Communit Dent [serial online] 2015 [cited 2020 Jan 25];5:335-40. Available from: http://www.jispcd.org/text.asp?2015/5/5/335/165933
| Introduction|| |
According to the World Oral Health Report, despite great improvements in oral health in several countries, oral health problems still persist, particularly among underprivileged groups in both developing and developed countries. Dental caries and periodontal diseases are identified as the most important among oral health problems globally. Oral diseases adversely affect the general health too. Quality of life and the working capacity of an individual are also affected.
The antibacterial agents that are currently used for treatment of oral health problems are reported to cause several side effects such as diarrhea, vomiting, etc., Increasing bacterial resistance to the drugs is also a major concern. Because of the adverse effects, increasing bacterial resistance, and high cost associated with the standard therapeutic procedure, there is a need to explore new therapeutic agents and conduct further clinical research on traditional medicines obtained from various plant sources.
Many traditionally used medicines for treating infections have been studied again, and clinical trials are being done to establish their efficacy and possible side effects. One of these natural medicines is essential oils (EOs)., In the recent years, there has been an increased interest toward EOs.
Approximately 3000 Eos are known till now. EOs are one of the plant extracts that have been used for treatment of various medical and dental problems since ancient times. These are secondary metabolites produced by various medicinal plants and possess antibacterial, antifungal, and antioxidant properties.,,
The purpose of this systematic review is to analyze the published data related to the EOs. A number of studies have been conducted to prove the therapeutic properties of various EOs, but very few reviews have been published on their implication in dental treatment. The review gives an overview on the EOs, their therapeutic properties, and adverse effects.
| Materials and Methods|| |
To identify relevant literature, an electronic search was performed on PubMed database.
Titles and abstracts were screened. Only articles related to lavender oil, eucalyptus oil, clove oil, cinnamon oil, and lemon EOs have been included in this review. Studies related to several other EOs were excluded. Total 52 articles found relevant were selected for this review.
EOs and their composition
EOs are secondary metabolites of plants whose constituents are basically a complex mixture of terpenic hydrocarbons, especially monoterpenes and sesquiterpenes, and oxygenated derivatives such as aldehydes, ketones, epoxides, alcohols, and esters. EOs greatly differ in their compositions. Even the composition of EOs extracted from the plants of same species differ in different geographic locations. Composition also depends on the maturity of the plant from which the EOs are extracted.,
Mechanism of action
The mechanisms of action of EOs are dependent on their chemical composition and the location of one or more functional groups on the molecules present in them.
Membrane damage is proposed to be the main mechanism of action. Solubility of EOs in the phospholipid bilayer of cell membranes seems to have an important role in their antimicrobial activity. Clove oil has reported to reduce the quantity of ergosterol which is found specifically in fungal cell membrane. Terpenoids in EOs have been found to interfere with the enzymatic reactions of energy metabolism.
Essential oils that have potential to be used in oral disease prevention and treatment are discussed subsequently.
Major components found are linalool, linalyl acetate, 1,8-cineole, B-ocimene, terpinen-4-ol, l-fenchone, camphor, and viridiflorol., However, the relative level of each of these constituents varies in different species. Lavender oil, obtained from the flowers of Lavandula angustifolia (Family: Lamiaceae) by steam distillation, is chiefly composed of linalyl acetate (3,7-dimethyl-1,6-octadien-3yl acetate), linalool (3,7-dimethylocta-1,6-dien-3-ol), lavandulol, 1,8-cineole, lavandulyl acetate, and camphor.
The activity of linalool reflects that of the whole oil, indicating that linalool may be the active component of lavender oil.
- Antimicrobial activity: EOs extracted from Lavandula stoechas L. exhibit good antimicrobial activities against most of the bacteria, filamentous fungi, and yeasts. In the study of Benabdelkader et al., minimum inhibitory concentrations were found to be ranging from 0.16 to 11.90 mg/ml. It also shows antipseudomonal activity 
- In vitro study on the antibacterial activity of the EO of Lavandula coronopifolia against antibiotic-resistant bacteria suggested its bactericidal effect 
- Anxiolytic: Lavender EO is reported to reduce stress, anxiety, and improve mood when inhaled or orally administered., It is not very effective in cases of high anxiety 
- Antifungal: EOs of Lavandula luisieri show an inhibitory effect on yeast, dermatophyte, and Aspergillus strains.Lavandula viridis is reported to have fungicidal effect. Cryptococcus neoformans is the most sensitive fungus, followed by Candida species.
The main component is 1,8-cineole followed by cryptone, α-pinene, p-cymene, α-terpineol, trans-pinocarveol, phellandral, cuminal, globulol, limonene, aromadendrene, spathulenol, and terpinene-4-ol.
- Antimicrobial effect: Antimicrobial activity was found to be related to the synergic effects between major and minor components rather than the concentration of a single component. EO of the leaves of Eucalyptus globulus has antimicrobial activity against Gram-negative bacteria (Escherichia coli) as well as Gram-positive bacteria (Staphylococcus aureus). Studies done on eight eucalyptus species show that Eucalyptus odorata oil possesses strong cytotoxic effect and also antibacterial effect against S. aureus, Haemophilus influenzae, Staphylococcus pyogenes, and Staphylococcus pneumonia. Eucalyptus bicostata and Eucalyptus astringens showed antibacterial effects 
- Anti-inflammatory effect: Immunoregulatory agent: The study of Serafino et al. demonstrates that eucalyptus EO can stimulate the innate cell-mediated immune response suggesting its use as adjuvant in immunosuppression, in infectious disease, as well as in tumor chemotherapy.
- Peppermint oil
Peppermint (Mentha piperita) oil is one of the most popular and widely used EOs. In the EO from M. piperita, menthol is identified as the major compound, followed by menthyl acetate and menthofuran.
- Antibacterial: Peppermint oil shows an inhibitory effect on the proliferation of staphylococci 
- Antifungal: Studies show that EOs exhibit fungistatic and fungicidal activities against both the standard and clinical strains of Candida species at concentrations ranging from 0.5 to 8 μL/mL. EOs exhibit similar antifungal effect against the azole-resistant and azole-susceptible strains 
- Antibiofilm: Biofilm inhibition in fungal strains helps to decrease pathogenesis and drug resistance. Studies show that EO inhibits the biofilm formation of Candida albicans completely up to 2 μl/ml in a dose-dependent manner.
Melaleuca alternifolia (Myrtaceae)
It is also known as Tea Tree Oil (TTO). Its composition shows terpinen-4-ol, γ-terpinene, p-cymene, α-terpinene, 1,8-cineole, α-terpineol, and α-pinene.
- Antibacterial: In a clinical trial, the melaleuca gel was found to possess an inhibitory effect on various bacterial colonies and dental biofilm. It shows strong antibacterial action against oral pathogens 
- Antifungal activity: Melaleuca alternifolia possesses antimycotic activity, terpinen-4-ol being its most effective component.
Mostly, it contains almost exclusively terpenes and oxygenated terpenes.
Therapeutic activity shows antifungal potential against three Candida species (C. albicans, Candida tropicalis, and Candida glabrata). Lemon EO is suggested to be used as an effective remedy against candidiasis caused by C. albicans.,
Main constituents found in the clove bud oil are the phenylpropanoids eugenol, eugenyl acetate, carvacrol, thymol, cinnamaldehyde, β-caryophyllene, and 2-heptanone, when analyzed by gas chromatography.,
Eugenol is well-known for its therapeutic properties and is widely used in dentistry.
- Antioxidant: When tested against tert-butylated hydroxytoluene, EO exhibited a very strong radical scavenging activity 
- Antifungal: It possesses antifungal activity. Clove oil and its main content eugenol also reduce the quantity of ergosterol, which is a specific component of fungal cell membrane. Germ tube formation by C. albicans is also inhibited 
- • Antibacterial: It was found to possess inhibitory effect on multi-resistant Staphylococcus spp.
The volatile oils obtained from the bark, leaf, and root barks vary significantly in chemical composition. Three of the main components of the EOs obtained from the bark of Cinnamomum zeylanicum are trans-cinnamaldehyde, eugenol, and linalool, which represent 82.5% of the total composition. Cinnamaldehyde is the major constituent of cinnamon EO, and studies show that it is the most active component too.
Antimicrobial effect: Inhibitory effect on the growth of various isolates of bacteria including Gram-positive, Gram-negative, and fungi.
Antimutagenic: It has antimutagenic potential against spontaneous mutations in human cells. Furthermore, the study of Cabello et al. performed in animals shows that oral administration of cinnamaldehyde (CA) exerts significant anti-melanoma activity.
Besides these activities, studies suggest that cinnamomum zeylanicum (CZ) has antiparasitic, antioxidant, and free radical scavenging properties.
Implications in dental practice
Potential implications of EOs have been described below and the information is consolidated in [Table 1].
It can be used in dental clinics to reduce patients' anxiety. It is found to be useful as an anxiolytic agent when used in waiting area., The study performed by Zabirunnisa showed statistically significant reduction in anxiety scores when the fragrance of lavender oil was used at the reception area. It is also helpful during surgical procedures, as it has been shown to reduce the pain of needle insertion.
It shows an inhibitory effect on oral pathogens like Lactobacillus acidophilus, which makes this suitable to be used as an anticariogenic agent.
Eugenol oil is used widely in dentistry. It is active against oral pathogens associated with dental caries and periodontal disease. Studies done on five EOs (TTO, lavender oil, thyme oil, peppermint oil, and eugenol oil) against four common oral pathogens (S. aureus, Enterococcus faecalis, E. coli, and C. albicans) showed significant inhibitory effect of eugenol oil, peppermint oil, and TTO. Among them, eugenol oil showed antimicrobial activity at the lowest concentration level.
TTO and some of its individual components, specifically terpinen-4-ol, exhibit strong antimicrobial efficacy against fungal biofilms. TTO can be a solution for the increasing resistance of C. albicans to established antifungal drugs. It can be used to treat oral candidiasis  and is suitable for use in prophylactic oral hygiene products. The study performed by Ramage et al. shows that it is more appropriate and safe to use terpinen-4-ol, the major component of TTO, than TTO itself.
A Phase I clinical trial conducted on cinnamon EO concluded that it is safe to be used in healthy patients with dentures for the treatment of oral candidiasis.
Lemon EO is suggested to be used as an effective remedy against candidiasis caused by C. albicans.
Combination of EOs
Combining EOs and antibiotics can reduce antibiotic resistance in multidrug-resistant bacteria. Peppermint, cinnamon bark, and lavender EOs were found to be antibiotic resistance-modifying agents, when used in combination with piperacillin.
Studies not supporting the use of EOs
Several studies support the benefits of EOs, but some studies raise questions about their efficacy.
A study in which 0.2% chlorhexidine rinse and an EO mouth rinse were compared for their efficacy showed that EOs are effective only for very short duration, i.e., 2–3 h, and concluded that use of chlorhexidine is preferable over EOs.
A study done on EOs to measure their efficacy when used as a coolant concluded that there was no benefit over water during ultrasonic root debridement for the treatment of chronic periodontitis.
Adverse effects caused by EOs
Natural medicines are not always free of side effects. Adverse effects are also reported with EOs. In the study of Millet et al., commercial preparations of essences of sage, hyssop, thuja, and cedar have been reported to cause neurotoxicity and human intoxication, of which tonic–clonic convulsions formed the major symptom.
According to a review by Posadzki et al., mild to severe adverse effects including fatality can be caused by EOs like lavender, peppermint, TTO, and ylang-ylang when used in aromatherapy. Most common adverse effect among them was dermatitis.
Toxicological tests are often lacking for traditional medicines. Therefore, further clinical trials are required to exclude the possibility of side effect and poisoning.
Only seven EOs that are found to be used commonly are included in this review. The review is subjected to publication bias as it is written on the basis of published literature. Only English language articles were referred. Article search was performed only in one database, PubMed.
| Conclusions|| |
As described in this review, there is considerable evidence that EOs have potential to be developed as preventive or therapeutic agents for various oral diseases. Although several other potential uses of EOs have been described  and many claims of therapeutic efficacy have been validated adequately by either in vitro testing or in vivo clinical trials, still there is need for conducting further research to establish the safety and efficacy of these EOs before including them in clinical practice. If used properly, they may prove very useful in dental therapy and may contribute in improving the quality of dental treatments.
In particular, clinical trials that confirm the therapeutic potential of EOs in vivo and address issues such as adverse effects, toxicity, and their interaction with other drug molecules would be of great value.
| References|| |
Petersen PE. The World Oral Health Report 2003: Continuous improvement of oral health in the 21st
century-the approach of the WHO Global Oral Health Programme. Community Dent Oral Epidemiol 2003;31(Suppl 1):3-23.
Palombo EA. Traditional medicinal plant extracts and natural products with activity against oral bacteria: Potential application in the prevention and treatment of oral diseases. Evid Based Complement Alternat Med 2011;2011:680354.
Cowan MM. Plant products as antimicrobial agents. Clin Microbiol Rev 1999;12:564-82.
Kalemba D, Kunicka A. Antibacterial and antifungal properties of essential oils. Curr Med Chem 2003;10:813-29.
Thosar N, Basak S, Bahadure RN, Rajurkar M. Antimicrobial efficacy of five essential oils against oral pathogens: An in vitro
study. Eur J Dent 2013;7(Suppl 1):S71-7.
Baratta MT, Dorman HJ, Deans SG, Figueiredo AC, Barroso JG, Ruberto G. Antimicrobial and antioxidant properties of some commercial essential oils. Flavour Fragr J 1998;13:235-44.
Hammer KA, Carson CF, Riley TV. Antimicrobial activity of essential oils and other plant extracts. J Appl Microbiol 1999;86:985-90.
Guleria S, Tiku AK, Koul A, Gupta S, Singh G, Razdan VK. Antioxidant and antimicrobial properties of the essential oil and extracts of Zanthoxylum alatum
grown in north-western Himalaya. Scientific World Journal 2013;2013:790580.
Rehman SU, Ahmad MM, Kazmi ZH, Raza MS. Physico-chemical variations in essential oils of Citrus reticulata
. J Food Sci Technol 2007;44:353-6.
Benabdelkader T, Zitouni A, Guitton Y, Jullien F, Maitre D, Casabianca H, et al.
Essential oils from wild populations of Algerian Lavandula stoechas
L.: Composition, chemical variability, and in vitro
biological properties. Chem Biodivers 2011;8:937-53.
Kiran CR, Chakka AK, Amma KP, Menon AN, Kumar MM, Venugopalan VV. Influence of cultivar and maturity at harvest on the essential oil composition, oleoresin and -gingerol contents in fresh ginger from northeast India. J Agric Food Chem 2013;61:4145-54.
Dorman HJ, Deans SG. Antimicrobial agents from plants: Antibacterial activity of plant volatile oils. J Appl Microbiol 2000;88:308-16.
Prashar A, Locke IC, Evans CS. Cytotoxicity of lavender oil and its major components to human skin cells. Cell Prolif 2004;37:221-9.
Pinto E, Vale-Silva L, Cavaleiro C, Salgueiro L. Antifungal activity of the clove essential oil from Syzygium aromaticum
and dermatophyte species. J Med Microbiol 2009;58:1454-62.
Knobloch K, Pauli A, Iberl B, Weis N, Weigand H. Antibacterial activity and antifungal properties of essential oil components. J Essent Oils Res 1988;1:119-28.
Végh A, Bencsik T, Molnár P, Böszörményi A, Lemberkovics E, Kovács K, et al.
Composition and antipseudomonal effect of essential oils isolated from different lavender species. Nat Prod Commun 2012;7:1393-6.
Ait Said L, Zahlane K, Ghalbane I, El Messoussi S, Romane A, Cavaleiro C, et al.
Chemical composition and antibacterial activity of Lavandula coronopifolia
essential oil against antibiotic-resistant bacteria. Nat Prod Res 2015;29:582-5.
Lehrner J, Marwinski G, Lehr S, Johren P, Deecke L. Ambient odors of orange and lavender reduce anxiety and improve mood in a dental office. Physiol Behav 2005;86:92-5.
Kim S, Kim HJ, Yeo JS, Hong SJ, Lee JM, Jeon Y. The effect of lavender oil on stress, bispectral index values, and needle insertion pain in volunteers. J Altern Complement Med 2011;17:823-6.
Bradley BF, Brown SL, Chu S, Lea RW. Effects of orally administered lavender essential oil on responses to anxiety-provoking film clips. Hum Psychopharmacol 2009;24:319-30.
Zuzarte M, Gonçalves MJ, Cruz MT, Cavaleiro C, Canhoto J, Vaz S, et al. Lavandula luisieri
essential oil as a source of antifungal drugs. Food Chem 2012;135:1505-10.
Posadzki P, Alotaibi A, Ernst E. Adverse effects of aromatherapy: A systematic review of case reports and case series. Int J Risk Saf Med 2012;24:147-61.
Bachir RG, Benali M. Antibacterial activity of the essential oils from the leaves of Eucalyptus globulus against Escherichia coli
and Staphylococcus aureus
. Asian Pac J Trop Biomed 2012;2:739-42.
Yap PS, Lim SH, Hu CP, Yiap BC. Combination of essential oils and antibiotics reduce antibiotic resistance in plasmid-conferred multidrug resistant bacteria. Phytomedicine 2013;20:710-3.
Saharkhiz MJ, Motamedi M, Zomorodian K, Pakshir K, Miri R, Hemyari K. Chemical composition, antifungal and antibiofilm activities of the essential oil of Mentha piperita
L. ISRN Pharm 2012;2012:718645.
Witkowska D, Sowinska J. The effectiveness of peppermint and thyme essential oil mist in reducing bacterial contamination in broiler houses. Poult Sci 2013;92:2834-43.
Pereira TS, de Sant'anna JR, Silva EL, Pinheiro AL, de Castro-Prado MA.In vitro
genotoxicity of Melaleuca alternifolia
essential oil in human lymphocytes. J Ethnopharmacol 2014;151:852-7.
Santamaria M Jr, Petermann KD, Vedovello SA, Degan V, Lucato A, Franzini CM. Antimicrobial effect of Melaleuca alternifolia
dental gel in orthodontic patients. Am J Orthod Dentofacial Orthop 2014;145:198-202.
Takarada K, Kimizuka R, Takahashi N, Honma K, Okuda K, Kato T. A comparison of the antibacterial efficacies of essential oils against oral pathogens. Oral Microbiol Immunol 2004;19:61-4.
Terzi V, Morcia C, Faccioli P, Valè G, Tacconi G, Malnati M.In vitro
antifungal activity of the tea tree (Melaleuca alternifolia
) essential oil and its major components against plant pathogens. Lett Appl Microbiol 2007;44:613-8.
Trombetta D, Castelli F, Sarpietro MG, Venuti V, Cristani M, Daniele C, et al.
Mechanisms of antibacterial action of three monoterpenes. Antimicrob Agents Chemother 2005;49:2474-8.
Białoń M, Krzyśko-Łupicka T, Koszałkowska M, Wieczorek PP. The influence of chemical composition of commercial lemon essential oils on the growth of Candida
strains. Mycopathologia 2014;177:29-39.
Chaieb K, Zmantar T, Ksouri R, Hajlaoui H, Mahdouani K, Abdelly C, et al
. Antioxidant properties of the essential oil of Eugenia caryophyllata
and its antifungal activity against a large number of clinical Candida species. Mycoses 2007;50:403-6.
Chaieb K, Hajlaoui H, Zmantar T, Kahla-Nakbi AB, Rouabhia M, Mahdouani K, et al.
The chemical composition and biological activity of clove essential oil, Eugenia caryophyllata
L. Myrtaceae): A short review. Phytother Res 2007;21:501-6.
Naveed R, Hussain I, Tawab A, Tariq M, Rahman M, Hameed S, et al.
Antimicrobial activity of the bioactive components of essential oils from Pakistani spices against Salmonella and other multi-drug resistant bacteria. BMC Complement Altern Med 2013;13:265.
Ooi LS, Li Y, Kam SL, Wang H, Wong EY, Ooi VE. Antimicrobial activities of cinnamon oil and cinnamaldehyde from the Chinese medicinal herb Cinnamomum cassia
Blume. Am J Chin Med 2006;34:511-22.
King AA, Shaughnessy DT, Mure K, Leszczynska J, Ward WO, Umbach DM, et al.
Antimutagenicity of cinnamaldehyde and vanillin in human cells: Global gene expression and possible role of DNA damage and repair. Mutat Res 2007;616:60-9.
Oliveira Jde A, da Silva IC, Trindade LA, Lima EO, Carlo HL, Cavalcanti AL, et al.
Safety and tolerability of essential oil from Cinnamomum zeylanicum
blume leaves with action on oral candidosis and its effect on the physical properties of the acrylic resin. Evid Based Complement Alternat Med 2014;2014:325670.
Ramage G, Milligan S, Lappin DF, Sherry L, Sweeney P, Williams C, et al.
Antifungal, cytotoxic, and immunomodulatory properties of tea tree oil and its derivative components: Potential role in management of oral candidosis in cancer patients. Front Microbiol 2012;3:220.
Ranasinghe P, Pigera S, Premakumara GA, Galappaththy P, Constantine GR, Katulanda P. Medicinal properties of 'true' cinnamon (Cinnamomum zeylanicum
): A systematic review. BMC Complement Altern Med 2013;13:275.
Elaissi A, Rouis Z, Salem NA, Mabrouk S, ben Salem Y, Salah KB, et al.
Chemical composition of 8 eucalyptus species' essential oils and the evaluation of their antibacterial, antifungal and antiviral activities. BMC Complement Altern Med 2012;12:81.
Ishnava KB, Chauhan JB, Barad MB. Anticariogenic and phytochemical evaluation of Eucalyptus globules
Labill. Saudi J Biol Sci 2013;20:69-74.
Cai L, Wu CD. Compounds from Syzygium aromaticum
possessing growth inhibitory activity against oral pathogens. J Nat Prod 1996;59:987-90.
Serafino A, Sinibaldi Vallebona P, Andreola F, Zonfrillo M, Mercuri L, Federici M, et al.
Stimulatory effect of Eucalyptus
essential oil on innate cell-mediated immune response. BMC Immunol 2008;9:17.
van de Braak SA, Leijten GC. Essential Oils and Oleoresins: A Survey in the Netherlands and Other Major Markets in the European Union. Rotterdam: CBI Centre for the Promotion of Imports from Developing Countries; 1994. p. 116.
Jandourek A, Vaishampayan JK, Vazquez JA. Efficacy of melaleuca oral solution for the treatment of fluconazole refractory oral candidiasis in AIDS patients. AIDS 1998;12:1033-7.
Cabello CM, Bair WB 3rd
, Lamore SD, Ley S, Bause AS, Azimian S, et al
. The cinnamon-derived Michael acceptor cinnamic aldehyde impairs melanoma cell proliferation, invasiveness, and tumor growth. Free Radic Biol Med 2009;46:220-31.
Malhotra S, Yeltiwar RK. Evaluation of two mouth rinses in reduction of oral malodor using a spectrophotometric technique. J Indian Soc Periodontol 2011;15:250-4.
Millet Y, Jouglard J, Steinmetz MD, Tognetti P, Joanny P, Arditti J. Toxicity of some essential plant oils. Clinical and experimental study. Clin Toxicol 1981;18:1485-98.
Dagli N, Dagli R. Possible use of essential oils in dentistry. J Int Oral Health 2014;6:i-ii.
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