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ORIGINAL ARTICLE
Year : 2017  |  Volume : 7  |  Issue : 2  |  Page : 90-94

Assessment of effectiveness of fluconazole and clotrimazole in treating oral candidiasis patients: A comparative study


1 Department of Oral Medicine and Radiology, Chettinad Dental College and Research Institute, Kelambakkam, Tamil Nadu, India
2 Department of Oral Medicine and Radiology, Sri Venkateshwaraa Dental College, Puducherry, India
3 Department of Oral Medicine and Radiology, Rajas Dental College and Hospital, Tirunelveli, Tamil Nadu, India
4 Department of Oral and Maxillofacial Surgery, Adthiparasakthi Dental College and Hospital, Melmaruvathur, Tamil Nadu, India

Correspondence Address:
R C Jagat Reddy
Department of Oral Medicine and Radiology, Chettinad Dental College and Research Institute, Kelambakkam, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jispcd.JISPCD_34_17

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Aims: One of the most common fungal infections infecting humans is Candidiasis. Belonging to the group of opportunistic infections, it often affects individuals with various debilitating diseases. Fluconazole and clotrimazole are two of the commonly used anti-fungal agents for the treatment of oral candidiasis. Hence, we planned this study to evaluate the effectiveness of fluconazole and clotrimazole in the treatment of patients suffering from candidiasis. Materials and Methods: A total of 180 participants were enrolled in the present study. All the patients of candidiasis were divided broadly into two study groups. Group I included patients who were treated with fluconazole mouthrinse whereas group II included patients who were treated with clotrimazole mouth paint. Grading of patient discomfort was done as noted from readings given by the patients. Specimen was collection by a swab from the lesional area of the oral cavity from the patients and were incubated in Sabouraud's dextrose agar medium and assessed. All the patients were treated with medication as give to their respective groups. Patients were recalled as assessed. All the readings were recorded and analyzed. Results: For group I patients, the fungal eradication was 89.5%, whereas for group II patients, the fungal eradication was 86.7%. No significant results were obtained while comparing the mycological eradiation in patients of the two study groups. Conclusion: Approximately similar effectiveness in terms of treatment was noted with fluconazole and clotrimazole in treating patients with candidiasis.


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