|Year : 2018 | Volume
| Issue : 4 | Page : 304-308
|The relationship between agenesis of third molar and craniofacial morphology in orthodontic patients
Mahdjoube Goldani Moghadam1, Farzane Etemadi1, Narjes Akbari2
1 Department of Orthodontics, Faculty of Dentistry, School of Dentistry, Birjand University of Medical Sciences, Birjand, Iran
2 Department of Oral Medicine, Faculty of Dentistry, School of Dentistry, Birjand University of Medical Sciences, Birjand, Iran
|Date of Submission||09-Mar-2018|
|Date of Acceptance||15-May-2018|
|Date of Web Publication||18-Jul-2018|
Dr. Narjes Akbari
Faculty of Dentistry, Birjand University of Medical Sciences, Birjand
Source of Support: None, Conflict of Interest: None
| Abstract|| |
Aims and Objectives: The aim of this study was to evaluate the association between third molar agenesis and craniofacial morphology in a group of Iranian orthodontic patients.
Materials and Methods: A total of 164 high-quality lateral cephalograms and panoramic radiographs were included in the study. Eighty-two radiographs with the absence of at least one-third molar were assigned to agenesis group and other 82 radiographic records were served as control group. Cephalometric analysis was performed, and the results were compared between the two groups using Independent Samples Student's t-test.
Results: Significant differences were found in SNA, ANB, sum of posterior angles, and lower gonial angle between the study groups. All of them were smaller in the agenesis group.
Conclusion: Third molar agenesis in this group of Iranian subjects is associated with deficient maxillary development and brachyfacial and hypodivergent skeletal pattern.
Keywords: Agenesis, craniofacial morphology, third molar
|How to cite this article:|
Moghadam MG, Etemadi F, Akbari N. The relationship between agenesis of third molar and craniofacial morphology in orthodontic patients. J Int Soc Prevent Communit Dent 2018;8:304-8
|How to cite this URL:|
Moghadam MG, Etemadi F, Akbari N. The relationship between agenesis of third molar and craniofacial morphology in orthodontic patients. J Int Soc Prevent Communit Dent [serial online] 2018 [cited 2018 Oct 23];8:304-8. Available from: http://www.jispcd.org/text.asp?2018/8/4/304/237061
| Introduction|| |
Congenital absence of teeth is a fairly common phenomenon. It has been found to be the most frequently occurring anomaly of dentition. Dental agenesis (hypodontia) is defined as the case that at least one of the individual's teeth is congenitally not formed. Hypodontia can occur in any tooth, but it is more prevalent in some than other teeth. Agenesis in white race involves the most distal teeth, including the third molars, the second mandibular premolar, and maxillary lateral teeth.,,
The worldwide prevalence of the absence of third molars has been reported to be 22.63%. It is 14% more likely to be found in women and maxillary agenesis is 36% more probable than mandibular agenesis. Crown and root morphology, time of formation, and presence or absence of the third molar tooth are all subjected to wide variations. The agenesis of third molars is frequently occurred, but the reported prevalence is different among different populations. The wide range of the prevalence of this type of anomaly is caused by differences in sample selection, assessment methods, samples' examination, and the gender, age, and race distribution of studied cases., A few studies addressed the rising prevalence of agenesis in the 20th century. Agenesis has been associated with the development of some other dental anomalies such as delay in teeth formation, delay in exfoliation, over retention of the primary teeth, and deficient growth of alveolar bone.
Agenesis can affect dentofacial and craniofacial structures. Few studies have evaluated this relation and yielded contradictory results. Some studies have suggested no relationship between the craniofacial structure and teeth agenesis; whereas a number of researchers have suggested a possible link between the size of the jawbone and agenesis. Some reports suggest that the same genes are involved in regulating both the craniofacial structure development and teeth morphogenesis. Some other studies have reported that agenesis does not affect the craniofacial structures and there is no evidence that the third molars are essential for jawbone growth., One study states that measurement of mandibular length in patients with third molars, compared to patients with congenital absence of mandibular third molar, showed no different growth patterns., In another study conducted in the Turkish population, the absence of third molars had a minor impact on dentofacial structures, and in a study on Japanese population, the absence of third molars was not associated with mandibular length but was associated with the anteroposterior dimension of maxilla. on the other hand, it has been found that the absence of third molars increases the likelihood of agenesis of other teeth 13 folds. It has been suggested that the functional compensation in subjects with advanced hypodontia may be responsible for the altered craniofacial structure and it may be irrelevant to agenesis in itself., Some studies have suggested a link between the absence of teeth and unusual morphology of the remaining teeth;, other studies have shown an association between agenesis of third molar and anomalies of other teeth. Some studies revealed evidence regarding that the presence of third molars is required for the development of the maxilla and mandibular bones.
To the best of our knowledge, the association of third molar agenesis and craniofacial structures has not been yet evaluated in the Iranian population. Therefore, regarding conflicting results of previous studies on this topic, the aim of this study was to evaluate the association between agenesis of third molars and craniofacial morphology in orthodontic patients, admitted to Dental School of Birjand University of Medical Sciences.
| Materials and Methods|| |
In this cross-sectional study, radiographic records of patients who referred to Orthodontic Clinic of Dental school of Birjand University of Medical Sciences in 2016 were reviewed, of which 164 records were selected. The study protocol was approved by the Ethics Committee (no: 139547) of Birjand University of Medical Sciences, Birjand, Iran. The sample size was calculated based on a previous study  and sample size calculation formula. Lateral cephalograms and panoramic radiographs of high quality of 82 patients who had at least one-third molar agenesis were selected as the agenesis group, and 82 others which had all four third molars were assigned to the control group.
The mean age of subjects was 24.9 ± 5.4 years in the agenesis group and 24.9 ± 5.2 years in the control group. The group with agenesis (n = 82) consisted of 49 women and 33 men and in the control group (n = 82), 58 were women and 24 were men.
Inclusion criteria for the agenesis group included the absence of at least one-third molar and high-quality radiographs. Agenesis of the third molar was diagnosed, when radiographic sign of crown mineralization of third molar could not be observed, whereas the second mandibular molar was in the seventh or G stage or higher according to the method of Demirjain (mineralization of bifurcation was initiated). Subjects with congenital disorders and deformities such as cleft palate or any other syndrome or absence of any teeth, other than third molars, and subjects with a history of previous orthodontic treatment were excluded from the study.
Pretreatment cephalometric radiographs were analyzed. Cephalometric analysis was done using measurements from Wits, Steiner (SNA, SNB, and ANB), Ricketts (lower face height, corpus Length, mandibular plane, facial axis, and palatal plan), and Jarabak (lower gonial angle, face height ratio, mandibular body length, saddle angle, articular angle, gonial angle, and upper gonial angle) analysis. Lateral cephalograms of all subjects were hand traced by one investigator on acetate paper overview box and the tracing was further reviewed by other authors for accuracy. The reference points and planes used in this study are shown in [Figure 1]. The following skeletal and the following measurements were made and compared between the groups:
- SNA (Steiner analysis): Anteroposterior position of maxilla in relation to the anterior cranial base
- SNB (Steiner analysis): Anteroposterior position of mandible in relation to the anterior cranial base
- ANB (Steiner analysis): The difference between the SNA and SNB
- Wits (mm): the distance between AO and BO on occlusal plane
- Facial axis (Ricketts analysis): Inferior angle made by the intersection of Ba-N and Pt-Gn
- Mandibular plane angle (Ricketts Analysis): The angle formed by the intersection of mandibular plane (Me-Go) and Frankfort plane (FH)
- Lower face height (Ricketts Analysis): The angle established by the intersection of two planes: ANS-Xi and Xi-Pog
- Corpus length (Ricketts analysis): The angle between DC-Xi and corpus axis
- Saddle angle (Bjork-Jarabak): angle between S-N and S-Ar
- Articular angle (Bjork-Jarabak): angle between S-Ar and Go-Ar
- Gonial angle (Bjork-Jarabak): angle between Ar-Go and Go-Me
- Sum of S + A + Go angles (Bjork-Jarabak): The sum of posterior angles: saddle angle, articular angle, and gonial angle
- Upper gonial angle (Bjork-Jarabak): The upper angle made by Go-N plane which bisected gonial angle (the angle between Ar-Go-N)
- Lower gonial angle (Bjork-Jarabak): The lower angle made by Go-N plane which bisected gonial angle (the angle between N-Go-Me)
- Face height ratio (%): The ratio of the posterior (S-Go) and anterior (N-Me) face height
- Palatal plane length (ANS-PNS) (mm) (Ricketts Analysis): The distance between ANS and PNS
- Mandibular body length (Go-pog) (mm) (Bjork-jarabak): the distance between Go-Pog.
One month after the first measurement, 20 cephalograms were analyzed again in each group by the same person to assess the reproducibility which showed intraclass correlation coefficient of 0.95 indicating good reproducibility.
For each of the cephalometric parameters, mean and standard deviation were calculated using the Statistical Package for the Social Sciences (SPSS) version 18 for Windows (SPSS, Inc., Chicago, Illinois, USA). Independent samples Student's t-test was used to make a comparison between agenesis and control groups. Statistical significance was considered to be P ≤ 0.05.
| Results|| |
A total of 164 patients were examined in this study, 82 of whom had agenesis of third molar (the agenesis group) and 82 others had four third molars present (the control group). The mean age of patients was 24.9 ± 5.4 years in the agenesis group and 24.9 ± 5.2 years in the control group (P = 0.98, t = 0.02). The results of t-test showed insignificant differences in mean age between the study groups. Based on the data of this study, there was no significant difference in sex frequency between the two groups (P = 0.14).
As can be seen from [Table 1], mean value of SNA and ANB angles in the control group was significantly higher than the agenesis group (P = 0.02). As [Table 1] shows, there is a significant difference in sum of posterior angles and lower gonial angle between the agenesis and the control groups. Comparison of other measurements revealed insignificant difference between the two groups.
|Table 1: Descriptive statistics including means and standard deviations as well as comparison of cephalometric measurements in the agenesis and control groups|
Click here to view
| Discussion|| |
The agenesis and control groups were adequately matched in this study which is confirmed by insignificant differences in age and sex frequencies of subjects in the two groups. The mean age of the subjects was 24.9 ± 5.4 years in the agenesis group and 24.9 ± 5.2 years in the control group. To evaluate the agenesis of the third molar in this study, dental age was used. It has been said that the third molar crypt can be radiographically observed at 5 years and 10 months of age. Early and late formation of third molar was stated to be at 9 and 14–16 years of age, respectively., According to Massler et al., the third molar cavity is formed at the ages of 3–4 years. Between the ages of 7–10 years, third molars start to calcify; between the ages of 12 and 16, the teeth crowns become completely calcified; and between ages of 17 and 21 years, third molars start to erupt. All the subjects in this study had passed these time limits; therefore, the diagnosis of third molar agenesis could be made easily.
The main question which was planned to be answered by this study was whether there is a relationship between third molar agenesis and craniofacial morphologies in sagittal and vertical planes or not. We hypothesized that sagittal and vertical dimension changes are associated with third molar agenesis. As previously described, to evaluate the main hypothesis of this study, we designed a cross-sectional study which was conducted on a group of orthodontic patients who had high quality panoramic and cephalometric radiographs and met the inclusion criteria of the study. The intraexaminer reproducibility was assessed, and the data were analyzed using appropriate statistical tests as mentioned earlier.
To summarize the main findings revealed by this study, we found that, in subjects with agenesis of one or more third molar teeth, the SNA, sum of posterior angles, and lower gonial angle were significantly lower compared to the control group.
As mentioned above, in this study, we found significantly lower SNA and therefore ANB angles in the agenesis group. This finding is further supported by previous studies. A study conducted in a group of Japanese showed lesser sagittal dimensions of the basal bone of the maxilla in subjects with bilateral maxillary third molar agenesis. However, they failed to show any association between third molar agenesis and anteroposterior dimensions of the mandible, which further supports our observation in this respect. Kömerik et al. in their study to evaluate the relationship between third molar agenesis and skeletal jaw morphologies in sagittal and vertical planes showed that agenesis of third molars was more prevalent in subjects with smaller sagittal maxillary and mandibular dimensions. They also found that subjects with hypodivergent and short face pattern had a higher frequency of third molar agenesis in both jaws. In a recent study done by Huang et al., it was found that subjects with agenesis had smaller SNA and Wits values which are in line with our observations. They also found that hypodivergent subjects had a higher incidence of third molar agenesis  Altan et al. also found that anteroposterior dimensions of both jaws were significantly smaller in agenesis groups. However, they failed to find any difference in vertical dimensions among the groups. The association between tooth agenesis and significant decreases in maxillary jaw size has also been stated by Tavajohi-Kermani et al., while they observed insignificant changes in mandibular size associated with tooth agenesis. However, this result differs from those of Sánchez et al. and Ramiro-Verdugo et al. since they did not find a significant association between maxillary anteroposterior dimension and third molar agenesis. Racial differences can be a possible explanation for these differences. Some studies support a link between certain malocclusions and third molar agenesis. For example, a significantly higher prevalence of third molar agenesis was found in the Class II Division 2 group in Japan.
We found a significant association between agenesis of the third molar and smaller lower gonial angle in this study. A reduced gonial angle is representative of more horizontally directed mandibular growth and counter clockwise rotation of mandibular plane which are indicative of a brachycephalic head form. The lower sum of posterior angles in this study seems to be influenced by the lower gonial angle. This observation is consistent with that of Sánchez et al. who found that maxillary third molar agenesis was associated with reduced mandibular plane angle. They found decreased lower facial height and brachyfacial pattern in subjects with mandibular third molar agenesis. This also accords with findings of Ramiro-Verdugo et al., who found an association between third molar agenesis and reduction in Jarabak's gonial angle and upper gonial angle and brachyfacial skeletal pattern. Nevertheless, this observation is in contrast to findings of Celikoglu and Kamak, who reported the similar prevalence of third molar agenesis among the hyperdivergent, normal, and hypodivergent groups. Cocos and Halazonetis have also evaluated the shape of the craniofacial complex in patients with tooth agenesis and found that patients with agenesis of teeth other than third molars had Class III tendency and hypodivergent skeletal pattern, but this was not true for third molar agenesis group.
It has been recently claimed that the third molar agenesis could be a potential marker for craniofacial deformities and may be associated with the disturbances related to cleft lip and palate. Fernandez et al. in a study to evaluate the relationship between third molar agenesis and other craniofacial structure alterations found that there was high frequency of third molar agenesis among individuals with cleft lip and their relatives. However, they did not find an association with skeletal malocclusion or growth pattern.
Due to lacking systematic search protocols and similar criteria for appraising evidence on the relationship of third molar agenesis and craniofacial morphology, the literature lacks systematic reviews on the topic. However, there are systematic reviews about morphologic and demographic predictors of third molar agenesis and predictors of third molar impaction , which were irrelevant to the topic of this paper.
Within the limitation of this study, it can finally be implied that third molar agenesis is associated with sagittal and vertical jaw dimensions. However, further studies with larger samples are needed for presenting definitive conclusions.
| Conclusion|| |
Third molar agenesis in this group of Iranian subjects was associated with reduced SNA angle and decreased lower gonial angle which is suggestive of deficient maxillary development and brachyfacial and hypodivergent skeletal pattern in subjects with third molar agenesis.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Bergendal B, Olgart K. Congenitally missing teeth. InConsensus conference on oral implants in young patients. Jönköping: The Institute for Postgraduate Dental Education 1996. p. 16-27.
Sujon MK, Alam MK, Rahman SA. Prevalence of third molar agenesis: Associated dental anomalies in non-syndromic 5923 patients. PLoS One 2016;11:e0162070.
Sánchez MJ, Vicente A, Bravo LA. Third molar agenesis and craniofacial morphology. Angle Orthod 2009;79:473-8.
Endo T, Ozoe R, Yoshino S, Shimooka S. Hypodontia patterns and variations in craniofacial morphology in Japanese orthodontic patients. Angle Orthod 2006;76:996-1003.
Tavajohi-Kermani H, Kapur R, Sciote JJ. Tooth agenesis and craniofacial morphology in an orthodontic population. Am J Orthod Dentofacial Orthop 2002;122:39-47.
Yüksel S, Uçem T. The effect of tooth agenesis on dentofacial structures. Eur J Orthod 1997;19:71-8.
Carter K, Worthington S. Morphologic and demographic predictors of third molar agenesis: A systematic review and meta-analysis. J Dent Res 2015;94:886-94.
Celikoglu M, Kamak H. Patterns of third-molar agenesis in an orthodontic patient population with different skeletal malocclusions. Angle Orthod 2012;82:165-9.
Ramiro-Verdugo J, De Vicente-Corominas E, Montiel-Company JM, Gandía-Franco JL, Bellot-Arcís C. Association between third molar agenesis and craniofacial structure development. Am J Orthod Dentofacial Orthop 2015;148:799-804.
Flores-Mir C. Increased hypodontia through the twentieth century. Evid Based Dent 2006;7:15.
Bishara SE. Third molars: A dilemma! Or is it? Am J Orthod Dentofacial Orthop 1999;115:628-33.
Yuksel S, Uçem T. The effect of tooth agenesis on dentofacial structures. Eur J Orthod 1997;19:133-43.
Kajii TS, Sato Y, Kajii S, Sugawara Y, Iida J. Agenesis of third molar germs depends on sagittal maxillary jaw dimensions in orthodontic patients in Japan. Angle Orthod 2004;74:337-42.
Bailit HL. Dental variation among populations. An anthropologic view. Dent Clin North Am 1975;19:125-39.
Ogaard B, Krogstad O. Craniofacial structure and soft tissue profile in patients with severe hypodontia. Am J Orthod Dentofacial Orthop 1995;108:472-7.
Garn SM, Lewis AB. The gradient and the pattern of crown-size reduction in simple hypodontia. Angle Orthod 1970;40:51-8.
Vastardis H. The genetics of human tooth agenesis: New discoveries for understanding dental anomalies. Am J Orthod Dentofacial Orthop 2000;117:650-6.
Kokich VG, Kokich VO. Congenitally missing mandibular second premolars: Clinical options. Am J Orthod Dentofacial Orthop 2006;130:437-44.
Jorgenson RJ. Clinician's view of hypodontia. J Am Dent Assoc 1980;101:283-6.
Demirjian A, Goldstein H, Tanner JM. A new system of dental age assessment. Hum Biol 1973;45:211-27.
Steiner CC. Cephalometrics for you and me. Am J Orthod 1953;39:729-55.
Ricketts RM. Cephalometric analysis and synthesis. Angle Orthod 1961;31:141-56.
Jacobson A, Jacobson R. Radiographic Cephalometry, From Basics to 3D Imaging. 2nd
ed. New Malden, Surrey, UK: Quintessence Publishing Co.; 2006.
Bolaños MV, Moussa H, Manrique MC, Bolaños MJ. Radiographic evaluation of third molar development in Spanish children and young people. Forensic Sci Int 2003;133:212-9.
Gravely JF. A radiographic survey of third molar development. Br Dent J 1965;119:397-401.
Richardson M. Late third molar genesis: Its significance in orthodontic treatment. Angle Orthod 1980;50:121-8.
Massler M, Schour I, Poncher H. Developmental pattern of the child as reflected in the calcification pattern of the teeth. Am J Dis Child 1941;62:33-67.
Kömerik N, Topal O, Esenlik E, Bolat E. Skeletal facial morphology and third molar agenesis. J Res Pract Dent 2014.
Huang Y, Yan Y, Cao J, Xie B, Xiao X, Luo M, et al.
Obeservations on association between third molar agenesis and craniofacial morphology. J Orofac Orthop 2017;78:504-10.
Altan AB, Sinanoglu EA, Ucdemir E. Dentofacial morphology in third molar agenesis. Turk J Orthod 2015;28:7-12.
Ota K, Arai K. Prevalence and patterns of tooth agenesis in angle class II division 2 malocclusion in Japan. Am J Orthod Dentofacial Orthop 2015;148:123-9.
Cocos A, Halazonetis DJ. Craniofacial shape differs in patients with tooth agenesis: Geometric morphometric analysis. Eur J Orthod 2017;39:345-51.
Fernandez CC, Pereira CV, Luiz RR, Faraco IM Jr., Marazita ML, Arnaudo M, et al.
Third molar agenesis as a potential marker for craniofacial deformities. Arch Oral Biol 2018;88:19-23.
Carter K, Worthington S. Predictors of third molar impaction: A systematic review and meta-analysis. J Dent Res 2016;95:267-76.
| Article Access Statistics|
| Viewed||298 |
| Printed||26 |
| Emailed||0 |
| PDF Downloaded||98 |
| Comments ||[Add] |