Home | About us | Editorial board | Search | Ahead of print | Current issue | Archives | Submit article | Instructions| Reviewers

Login 
  Home Print this page Email this page Small font sizeDefault font sizeIncrease font size Users Online: 576    
     
ORIGINAL ARTICLE
Year : 2019  |  Volume : 9  |  Issue : 2  |  Page : 205-209

Evaluation of levels of proinflammatory chemokines MIP-1α and MIP-1β in gingival crevicular fluid of primary, mixed and permanent dentition


1 Department of Pedodontics and Preventive Dentistry, Malla Reddy Dental College for Women, Hyderabad, Telangana, India
2 Department of Oral Medicine and Radiology, Government Dental College and Hospital, RIMS, Kadapa, Andhra Pradesh, India
3 Senior Lecturer, Faculty of Dentistry, AIMST University, Kedah, Darul Aman, Malaysia

Correspondence Address:
Dr. B Swathi
Department of Pedodontics and Preventive Dentistry, Malla Reddy Dental College for Women, Hyderabad, Telangana
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jispcd.JISPCD_438_18

Rights and Permissions

Aim: This study aims to find out the proinflammatory chemokines macrophage inflammatory protein (MIP)-1α and MIP-1β levels in gingival crevicular fluid (GCF) of primary, mixed, and permanent dentitions. Materials and Methods: GCF of 160 individuals (4–15 years of age) was collected by the extracrevicular method. They were categorized into four groups (40 per each group). Group I: subjects with primary dentition (4–5 years of age), Group II: 40 subjects in early transition period (6–8 years), Group III: 40 individuals in the late transition period (9–11 years), and Group IV: 40 individuals with permanent dentition (12–15 years). MIP-lα and MIP-1β levels were determined in the samples of GCF by ELISA method. Data were analyzed by software SPSS Version 20 (IBM SPSS Statistics for Windows, IBM Corp., Armonk, NY: USA). Results: MIP-1α and MIP-1β were detected in all samples. The highest mean MIP-1α and MIP-1β concentrations in GCF were detected in the early transition period, while the lowest concentrations were seen in primary dentition group. The chemokine levels were higher in girls than in boys in Group III. There was a substantial rise of MIP-1α and MIP-1β levels during eruption. Conclusions: Since levels of MIP-1α and MIP-1β in GCF are positively associated with tooth eruption, they may perhaps be deemed as novel biomarkers in the eruption process.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed248    
    Printed23    
    Emailed0    
    PDF Downloaded57    
    Comments [Add]    

Recommend this journal