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REVIEW ARTICLE
Year : 2019  |  Volume : 9  |  Issue : 6  |  Page : 542-552

Comparison between iRoot BP Plus (EndoSequence Root Repair Material) and Mineral Trioxide Aggregate as Pulp-capping Agents: A Systematic Review


1 Department of General Dentistry, The First Affiliated Hospital of Xian Jiaotong University, Xian, China
2 Orthodontic Department Hospital of Stomatology Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China
3 Department of Orthodontics, College of Dentistry, Thamar University, Thamar, Yemen, China
4 Department of Preventive Dental Sciences, Najran University, Najran, Kingdom of Saudi Arabia
5 Private Practice, Yemen Medical Tower, Sana’a, Yemen, China
6 Department of General Dentistry, The First Affiliated Hospital of Xian Jiaotong University, Xian, Shaanxi, China

Correspondence Address:
Prof. Tao Hong
Department of General Dentistry, The First Affiliated Hospital of Xian Jiaotong University, 227 Yantaxi Road, Yanta District, Xian, Shaanxi, 710061 P.R.
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jispcd.JISPCD_249_19

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Introduction: iRoot BP Plus, also known as EndoSequence root repair material (EERM) is a premixed bioceramic thick/putty. According to its instruction manual, iRoot BP Plus is composed of tricalcium silicate, zirconium oxide, tantalum pentoxide, dicalcium silicate, calcium sulfate, calcium phosphate monobasic, and filler agents. This systematic review was carried out to evaluate and present the iRoot BP Plus material as a pulp-capping agent. Materials and Methods: A systematic search for articles with the scope of the selection criteria undergoing for data extraction was conducted through electronic databases. Studies on evaluation of the cytotoxicity, bioactivity, and dentinal bridge formation of iRoot BP, iRoot BP Plus, ERRM putty, or ERRM paste (ERRM) on variant human cells were selected for in vitro models, and dentinal bridge formation on human and animals teeth for in vivo models were selected. Results: A total of 22 articles were discussed in the review, 14 in vitro studies, five in vivo studies, and three articles with both studies. Methyl thiazol tetrazolium was the most used method for evaluating cytotoxicity. As for dentinal bridge formation, histological assessment and micro-Computed tomography were used. Human dental pulp cells (hDPCs) were the most investigated for in vitro models and rats for in vivo models. Except for one study, all studies involved in this review were primarily examining the material and comparing it to different types of mineral trioxide aggregate. Conclusion: iRoot BP, iRoot BP Plus, and ERRM are biocompatible materials that enhance hDPCs and other variant human cells proliferation, migration, attachment adhesion, mineralization, and dentinal bridge formation.


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