Journal of International Society of Preventive and Community Dentistry

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 7  |  Issue : 2  |  Page : 116--119

Prevalence of dentinogenesis imperfecta in a French population


Antoine Cassia1, Georges Aoun1, Abbass El-Outa2, Gérard Pasquet3, Robert Cavézian4,  
1 Department of Oral Pathology and Diagnosis, Lebanese University, Beirut, Lebanon
2 Dental Clinical Management, Faculty of Dental Medicine, Lebanese University, Beirut, Lebanon
3 Radiologist, Specialist in Dentomaxillofacial and Cephalic Diagnostic Imaging, France
4 Radiologist, Specialist in Dentomaxillofacial and Cephalic Diagnostic Imaging, Member of the French National Academy of Dental Surgery, Paris, France

Correspondence Address:
Georges Aoun
Department of Oral Pathology and Diagnosis, Faculty of Dental Medicine, Lebanese University, Beirut
Lebanon

Abstract

Background: Dentinogenesis imperfecta is a genetic disorder of the dentin occurring during the tooth development. It leads to many structural changes that can be identified clinically (brownish colored teeth, cracked enamel) and radiologically (globular crown, cervical constriction, short roots, and obliterated pulp chamber and/or root canals). The aim of this study was to determine by panoramic radiographs assessment the incidence of dentinogenesis imperfecta in a group of patients attending a specialized maxillofacial imaging center in Paris, France. Material and Methods: A retrospective observational study was conducted using panoramic radiographs of 8830 patients (3723 males and 5107 females), which were used to search the radiological criteria of dentinogenesis imperfecta. Results: In our sample, the prevalence of dentinogenesis imperfecta was 0.057%. Out of the 8830 subjects, 0.080% of the males presented the radiological signs of the dentinogenesis imperfecta against 0.039% of the females. Conclusion: In our study, we found that dentinogenesis imperfecta is a relatively rare dental anomaly in France, with a rate different from the rates reported in other studies and with no disparity in prevalence among genders.



How to cite this article:
Cassia A, Aoun G, El-Outa A, Pasquet G, Cavézian R. Prevalence of dentinogenesis imperfecta in a French population.J Int Soc Prevent Communit Dent 2017;7:116-119


How to cite this URL:
Cassia A, Aoun G, El-Outa A, Pasquet G, Cavézian R. Prevalence of dentinogenesis imperfecta in a French population. J Int Soc Prevent Communit Dent [serial online] 2017 [cited 2019 Aug 18 ];7:116-119
Available from: http://www.jispcd.org/text.asp?2017/7/2/116/203325


Full Text

 Introduction



Tooth structure anomalies may affect the enamel, the dentin, and the cementum. Dentinogenesis imperfecta (DI) is a genetic disorder of the dentin occurring during the tooth development. It was first described in the 19 th century and may affect the temporary and the permanent dentitions. [1] Literature reports only few studies on the epidemiology of DI (Witkop et al., [2] Gupta et al. [3] ). Furthermore, no such previous study was conducted on a French population.

Genetically, DI is inherited in a simple autosomal dominant mode. [4]

Shields et al. [5] classified DI into three types:

Type 1: DI associated with osteogenesis imperfecta.Type 2: DI identical clinically, radiologically, and histologically to type 1 but without being associated to osteogenesis imperfecta.Type 3: A rare DI involving, unlike types 1 and 2, teeth with shell-like appearance and multiple pulp exposures.

Many authors suggested that both type 2 and type 3 of DI are different expressions of the same gene. [6],[7],[8]

Clinically, the teeth color changes from brown to blue, occasionally described as amber or gray, with an opalescent sheen. Hypoplastic or hypocalcified defects may attack the enamel in about one-third of the patients causing it to crack away from the affected dentin. The latter becoming exposed may undergo severe and rapid attrition. [4],[9],[10]

Radiologically, the signs are pathognomonic of the affection. The crown is globular with marked cervical constriction, the roots are short, and the pulp chamber and/or the root canals are partially or totally obliterated [Figure 1]. [9],[11]{Figure 1}

The aim of this study was to determine, radiologically, the incidence of DI in France in patients attending a specialized maxillofacial imaging center located in Paris.

 Materials and Methods



In a retrospective statistical study including almost all the dental development anomalies, more precisely the dental agenesis, hypergenesis, dysmorphia, structural anomalies and transpositions, the archived panoramic radiographs of 8830 patients were assessed.

These patients were referred by their dentists to a specialized maxillofacial imaging center for multiple indications (e.g., impacted teeth, pre-prosthetic dental examinations, sinus diagnosis, etc.).

By the policy of the center, all patients were informed that the radiographs might be anonymously used for research purposes at a later stage and their consent was obtained. The study got the approval of the Center Institutional Board.

The exclusion criteria included all the radiographs presenting pathological changes or deformities in the mandible and/or maxilla. Random selection of radiographs in a reverse chronological order was followed until the desired number was reached.

The sample examined was formed of 3723 (42.16%) males and 5107 (57.83%) females.

The minimum needed sample size was calculated according to the following formula:

[INLINE:1]

where:

z= z-score (1.96 for a confidence level of 95%)

p= expected proportion (estimated 0.055% as it belongs to the range of prevalence rates in previous studies (prevalence ranged between 0.01 and 0.09)

d= marginal error (we chose it to be 0.05% in our study)

Therefore, our sample comprising 8830 subjects can be considered statistically representative.

The radiographs were assessed by two oral diagnosis specialists having more than 15 years of experience. Detailed discussion and standardization of diagnostic criteria between both examiners preceded image evaluation. Concerning evaluation period, it extended for one year (30 sessions of an average of 300 cases each with a period of one week existing between the sessions).

In this paper, we only discuss the presence of the DI among all the radiographically searched dental anomalies.

In order to make the radiologic diagnosis of the DI. three elements were searched:

The short dental rootsThe globular crowns with cervical constrictionsThe partial/total obliteration of the pulp cavities and/or the root canals.

For data entry and analysis, The Statistical Package for Social Sciences for Windows version 24 (IBM Corp., Armonk, New York) was used. Chi-square test and Fischer's exact test were used to test statistical significance; t-tests were used for hypotheses testing.

 Results



In our study, we examined the panoramic radiographs of 8830 patients [3723 (42.16%) males and 5107 (57.83%) females]. We found 5 patients with radiological signs of DI including 2 members (brother and sister) of the same family. Two of these patients had complete obliteration of the pulp chambers and root canals. The other 3 patients (including brother and sister) had a partial obliteration at each tooth or at the level of the entire dentition. The prevalence rate in our sample can be calculated as:

Prevalence of DI = (number of cases/sample size) × 100 = 0.057%

Dentinogenesis imperfecta is slightly more frequent in our population, in the male sex [3/5 (60%) against 2/5 (40% in females)]. It was not associated with any other teeth developmental anomaly.

 Discussion



Although several researchers have determined the prevalence of several dental anomalies, few have statistically analyzed DI prevalence and distribution; moreover, no such previous study was done in the French population. Since prevalence rate is very low, we can consider it approximately equal to the relative risk of DI.

The gender difference seems to be statistically insignificant (P > 0.05) [Table 1]. This suggests that DI is independent of sex. However, we cannot confirm independence due to the possibility of type II error. Therefore, a larger sample size, which decreases the risk of committing a type II error, would give more insight on this parameter.{Table 1}

According to de La Dure-Molla, [12] the only epidemiological data concerning DI was published in 1975. Witkop stated that DI estimated incidence was between 1/6000 and 1/8000. [2] These data only came from the United States. In other countries, case reports concerned smaller cohorts. [9],[13],[14],[15] A study on Indian population had a prevalence rate of DI of 0.09%; their results consisted of only one affected individual who was a male. [3] Therefore, gender difference could not be evaluated. [10]

Some data retrieved from the literature regarding the prevalence of DI are summarized in [Table 2].{Table 2}

Our study shows that the prevalence rate of DI in France is not in accordance with that in the aforementioned US and Indian populations. In all of the t-tests done to compare our prevalence rate with that of previous studies, null hypotheses were rejected and hence difference between rates was established (P < 0.05) [Table 3].{Table 3}

Aside from being the first study to evaluate DI prevalence rate in France, another strong point in our research is its statistically reliable sample size. Previous studies that assessed DI had questionable sample sizes. Our sample is statistically representative with an extremely low margin of error (0.05%). This allows us to claim that our results represent, by far, the most reliable numbers in literature on the prevalence of DI currently and can be considered a new and reliable reference for the prevalence rate for future epidemiological studies.

Despite that our study comprised a representative and reliable sample, one of its limitations is that a larger sample size would provide more definitive information on the prevalence of DI and, in particular, its gender predisposition; this was evident when we failed to prove or refute the gender difference. In addition, the absence of wide epidemiological studies in the literature and the variation of small studies results make it difficult to compare and analyze the obtained results with reference values.

 Conclusion



Dentinogenesis imperfecta is a hereditary developmental disorder of dentin that leads to structural changes of the affected teeth. It represents a very rare dental anomaly whose rate, in France, is different than that reported in other countries. DI incidence is gender neutral; there is no higher prevalence in one sex over another. The variation in the prevalence of our study in comparison with previous ones may be caused by consanguineous marriages in populations with higher prevalence rate, difference in diagnostic criteria of DI or due to racial differences. Despite being a relatively large study in a population that has not been assessed for DI before, larger epidemiological studies distributed in different populations would provide more insight on the distribution and predisposition of DI.

Acknowledgment

The authors would like to thank Dr. Ibrahim Nasseh for his technical help during the write up of the study.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

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