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Year : 2015  |  Volume : 5  |  Issue : 4  |  Page : 268-275

Comparative evaluation of the antibacterial and physical properties of conventional glass ionomer cement containing chlorhexidine and antibiotics

1 Department of Pedodontics, Himachal Dental College, Sunder Nagar, Himachal Pradesh, India
2 Department of Microbiology, Himachal Dental College, Sunder Nagar, Himachal Pradesh, India
3 Department of Pedodontics, Guru Nanak Dev Dental College and Research Institute, Sunam, Punjab, India

Correspondence Address:
Dr. Sudhir Mittal
Department of Pedodontics, Himachal Dental College, Sunder Nagar - 175 002, Himachal Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2231-0762.161754

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Objective: To evaluate the antimicrobial efficacy and compressive strength of conventional glass ionomer cement (GIC) containing chlorhexidine and antibiotics at varying concentrations. Materials and Methods: Chlorhexidine diacetate and antibiotics (ciprofloxacin, metronidazole, and minocycline) were incorporated into GIC Fuji IX at 1.5% and 3% w/w ratio to form the experimental groups. The experimental GIC specimens were placed on brain heart infusion agar plates inoculated with Streptococcus mutans, and the area of inhibition was measured after 48 h. The 24-h compressive strength of the set specimens was evaluated using a Universal Testing Machine. Results: The control group demonstrated no zone of inhibition. All experimental groups showed inhibition against S. mutans (P < 0.05), with larger zones of inhibition found in the higher concentration groups. Compressive strength at the end of 24 h decreased in the experimental groups as compared to the control group (P < 0.05), but no difference was found between the experimental groups (P > 0.05). Conclusion: The present study demonstrated that experimental GICs containing chlorhexidine diacetate and antibiotics were effective in inhibiting S. mutans, and incorporation of 1.5% ABX was optimal to give the appropriate antibacterial and physical properties.

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