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Year : 2016  |  Volume : 6  |  Issue : 1  |  Page : 49-53

Anti-Streptococcus mutans property of a chitosan: Containing resin sealant

1 Department of Microbiology, Babol University of Medical Sciences, Babol, Iran
2 Department of Microbiology, Dental Material Research Center, Babol, Iran
3 Department of Pediatrics, Babol University of Medical Sciences, Babol, Iran
4 Student's Research Committee, Babol University of Medical Sciences, Babol, Iran

Correspondence Address:
Maryam Ghasempour
Faculty of Dentistry, Dental Material Research Center, Babol University of Medical Sciences, Babol
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2231-0762.175405

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Objective: This study sought to assess the inhibitory effect of chitosan-containing sealants against Streptococcus mutans. Materials and Methods: The antibacterial activity of the resin sealant was evaluated by direct contact test following the addition of 0, 1, 2, 3, 4, and 5 wt% chitosan. At 3, 6, 9, 24 and 48 h, 1 and 3 months, 10 μl of the microbial suspension in contact with resin sealant was cultured to count the number of colonies. Data were analyzed by one-way one-way analysis of variance (ANOVA), repeated measures ANOVA, and Scheffe test. Results: The minimum inhibitory concentration of chitosan against S. mutans was 2 wt%. At 3 h, bacterial count in the presence of 2—5 wt% chitosan was significantly lower than that at 0 and 1 wt% (P < 0.05). However, this difference in bacterial count between 2 and 3 wt% chitosan and between 4 and 5 wt% chitosan was not significant. At 6 h, the difference in bacterial count between 3 and 4 wt% chitosan was not significant, whereas the remaining groups were significantly different in terms of bacterial count at this time (P < 0.05). At the remaining time points, significant differences were found between 2 wt% chitosan and higher concentrations (P < 0.05). Conclusion: Sealants containing 2—5 wt% chitosan show an antimicrobial property that is intensified by increasing the concentration of chitosan.

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