Journal of International Society of Preventive and Community Dentistry

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 5  |  Issue : 6  |  Page : 446--450

Evaluation of serum sialic acid, fucose levels and their ratio in oral squamous cell carcinoma


Sangamesh Ningappa Chinnannavar1, Lingappa Ashok2, Kodige Chandrashekhar Vidya1, Sunil Mysore Kantharaja Setty3, Guru Eraiah Narasimha4, Ranjana Garg5 
1 Department of Oral Medicine and Radiology, Kalinga Institute of Dental Sciences, Bhubaneswar, Odisha, India
2 Department of Oral Medicine and Radiology, Bapuji Dental College and Hospital, Davanagere, Karnataka, India
3 Department of Oral Medicine and Radiology, Gurunanak Dev Dental College, Sunam, Punjab, India
4 Department of Oral Medicine and Radiology, Vishnu Dental College, Bhimavaram, Andhra Pradesh, India
5 Department of Oral Medicine and Radiology, SEGI University College, Petaling Jaya, Malaysia

Correspondence Address:
Sangamesh Ningappa Chinnannavar
Department of Oral Medicine and Radiology, Kalinga Institute of Dental Sciences, Bhubaneswar, Odisha
India

Background: Detection of cancer at the early stage is of utmost importance to decrease the morbidity and mortality of the disease. Apart from the conventional biopsy, minimally invasive methods like serum evaluation are used for screening large populations. Thus, this study aimed to estimate serum levels of sialic acid and fucose and their ratio in oral cancer patients and in healthy control group to evaluate their role in diagnosis. Materials and Methods: Serum samples were collected from 52 healthy controls (group I) and 52 squamous cell carcinoma patients (group II). Estimation of serum levels of sialic acid and fucose and their ratio was performed. This was correlated histopathologically with the grades of carcinoma. Statistical analysis was done by using analysis of variance (ANOVA) test and unpaired "t" test. Results: Results showed that serum levels of sialic acid and fucose were significantly higher in oral cancer patients compared to normal healthy controls (P < 0.001). The sialic acid to fucose ratio was significantly lower in cancer patients than in normal controls (P < 0.01). However, comparison with histological grading, habits, gender, and age group did not show any significant result. Conclusion: The mean serum sialic acid and fucose levels showed an increasing trend from controls to malignant group and their corresponding ratio showed decreasing trend from controls to malignant group. The ratio of sialic acid to fucose can be a useful diagnostic aid for oral cancer patients.


How to cite this article:
Chinnannavar SN, Ashok L, Vidya KC, Setty SM, Narasimha GE, Garg R. Evaluation of serum sialic acid, fucose levels and their ratio in oral squamous cell carcinoma.J Int Soc Prevent Communit Dent 2015;5:446-450


How to cite this URL:
Chinnannavar SN, Ashok L, Vidya KC, Setty SM, Narasimha GE, Garg R. Evaluation of serum sialic acid, fucose levels and their ratio in oral squamous cell carcinoma. J Int Soc Prevent Communit Dent [serial online] 2015 [cited 2022 Jan 19 ];5:446-450
Available from: https://www.jispcd.org/article.asp?issn=2231-0762;year=2015;volume=5;issue=6;spage=446;epage=450;aulast=Chinnannavar;type=0